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Publications: Top Citations
Although great significance is attached to citation frequency in the academic scientific world, it is sometime difficult to know what drives interest in an individual publication. Some publications describe experiments that yield interesting results, more or less by accident. Others describe work that enable others to do new experiments, or better, that make a hypothetical proposition that motivates new experiments. Still, as anyone with experience will attest, many innovative ideas go unappreciated.
My favorite quote from Freeman Dyson:
"Most of the crackpot papers which are submitted to The Physical Review are rejected, not because it is impossible to understand them, but because it is possible. Those which are impossible to understand are usually published. When the great innovation appears, it will almost certainly be in a muddled, incomplete and confusing form. To the discoverer himself it will be only half-understood; to everybody else it will be a mystery. For any speculation which does not at first glance look crazy, there is no hope."
Still, this is mostly true for theoretical physics.
Top Citations (20+)
These stats were compiled on 9/2012.
Stacks Image 784
E primarily refers to an experimental result.
M primarily refers to an experimental tool or methodology.
T primarily refers to a theoretical observation based on structure or simulation.

Number Citations, Publication Number, Type (R-M-T), Publication Year, Title

798

53

E
1989

Structural Origins of High Affinity Biotin Binding to Streptavidin

444

47

M
1987

Use of an Imaging Proportional Counter in Macromolecular Crystallography

299

9

T
1976

A Hypothetical Structure for an Intermolecular Electron Transfer Complex of Cytochromes c and  b5.

262

89

M
2001

High Density Miniaturized Thermal Shift Assay as a General Strategy for Drug Discovery

200

10

T
1977

Structure and Function of Cytochrome c.

184

6

E
1973

The Structure of Oxidized Cytochrome c2 of Rhodospirillum rubrum.

173

72

E
1992

Crystallographic and Thermodynamic Comparison of Natural and Synthetic Ligands Bound  to Streptavidin  

169

18

T
1980

Structural and Functional Diversity in 4- a-Helical Proteins.

150

95

M
2005

Thermodynamic Stability Of Carbonic Anhydrase: Measurements Of Binding Affinity And Stoichiometry Using Thermofluor

149

40

E
1985

The Structure of Ferricytochrome c' from Rhodospirillum molischianum at 1.67 Å Resolution

135

31

T
1983

Structural Properties of Protein ß-Sheets

131

7

T
1973

Structural Bases for Function in Cytochrome c:  An Interpretation of Comparative X-ray and Biochemical Data. 

130

51

E
1989

Protein Crystal Growth in Microgravity

125

45

T
1987

Molecular Dynamics of a Cytochrome c-Cytochrome b5 Electron Transfer Complex

123

91

M
2003

Applications of Calorimetric Methods to Drug Discovery and the Study of Protein Interactions

116

3

M
1972

A Free Interface Diffusion Technique for the Crystallization of Proteins for X-ray Crystallography.

112

90

M
2002

Combinatorial Informatics in the Post-Genomics Era

105

29

T
1982

The a-Helix Dipole Model and Electrostatic Stabilization of a 4- a-Helical Proteins.

100

85

T
1999

Advances in diversity profiling and combinatorial series design.

86

60

T
1990

Competitor Analogs for Defined T Cell Antigens: Peptides Incorporating a Putative Binding Motif and Polyproline or Polyglycine Spacers

85

33

T
1983

Electrostatic Orientation During Electron Transfer Between Flavodoxin and Cytochrome c

78

76

E
1994

Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin

76

52

T
1989

Molecular Dynamics Simulation of a Phospholipid Micelle

60

20

E
1981

Crystallographic Structure of Rhodospirillum molischianum Ferricytochrome c' at 2.5 Å Resolution.

55

59

T
1990

A Molecular Dynamics Investigation of the Elastomeric Restoring Force in Elastin

54

81

M
1997

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery

37

94

M
2005

Decrypting the Biochemical Function of an Essential Gene from Streptococcus pneumoniae using Thermofluor Technology

35

22

T
1981

Conformational and Geometrical Properties of ß - Sheets in Proteins. III.  Isotropically Stressed Configurations.

34

66

T
1991

The Identification of Tyrosine as a Common Key Residue in Unrelated H-2Kd Restricted Antigenic Peptides

29

17

T
1979

Conformations of Twisted Parallel ß-Sheets and the Origin of Chirality in Protein Structures.

29

21

T
1981

On the Evolutionary Relationship of 4- a-Helical Heme Proteins.

28

78

E
1995

Crystallographic and Thermodynamic Comparison of Structurally Diverse Molecules Binding to Streptavidin

25

13

T
1977

Structural Convergence During Protein Evolution

23

82

E
1998

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors. 

22

27

T
1982

A Model for Catabolite Activator Protein Binding to Supercoiled DNA

22

48

E
1988

Molecular Factors Stabilizing Protein Crystals

22

73

T
1992

PROBIT: A Statistical Approach to Modeling Proteins from Partial Coordinate Data Using Substructure Libraries

21

93

M
2003

Chemical Genomics as an Emerging Paradigm for Postgenomic Drug Discovery

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